".... differences in response to adjuvants. To overcome the obstacle of low immunogenicity of an antigen, protein-based vaccines often use adjuvants to achieve adequate levels of protection. In individuals with a certain predisposition to develop autoimmunity, the excessive immune response can trigger autoimmune phenomena ".
Regarding the HPV vaccine, it has been estimated that the rate of ASIA syndrome is 3,6 cases per 100.000 doses of the HPV vaccine (95% CI 3,4-3,7). The most common clinical manifestations are pyrexia (58%), myalgia (27%) and arthralgia or arthritis (19%) ".
ASIA: Adjuvant-induced autoimmune / inflammatory syndrome