An investigation by PresaDiretta in the world of medicines, between antibiotic resistance and abuse. In Italy we use more antibiotics than in the rest of Europe, but do we always use them in the correct way? And what are the consequences of antibiotic resistance? And then the disorder in the use of drugs. According to the WHO, there are around 430 truly essential medicines, but there are thousands of those produced and marketed. So, are gastroprotectors, headache and migraine drugs, those for colds, statins and vitamin D against osteoporosis always used correctly? Finally, a trip by PresaDiretta to the United States, where there is a real epidemic of prescription opioids, mainly due to painkillers.