MALDI-TOF analysis technical report on the insoluble compound present in the Infanrix Hexa vaccine

MALDI-TOF analysis technical report on the insoluble compound present in the Infanrix Hexa vaccine

Remember the macromolecule we found in the Infanrix Hexa? What was indigestible, and which we had not been able to identify?

Here is the report of his analysis "MALDI-TOF" (methodology called into question by critics of the use of trypsin). The result, in simple terms, tells us that the macromolecule is a sort of "black hole" or sponge, which absorbs everything it comes into contact with.

It was not possible to "divide" it or identify any of its contents.


The conclusions

From the analyzes carried out it was not possible to identify the compound but to detect some chemical-physical properties on which to pay attention:

  1. Insolubility of the compound in polar media;
  2. Potential capacity of the compound to aggregate and sequester compounds present in the organic solution;
  3. Non-volatile compound even if irradiated with MALDI laser light.

It means that the compound is of high molecular weight and consists of a single large apolar macromolecule.

The characteristics mentioned above are typical of various compounds including:

  1. Functionalized resins (used for example in the MALDI variant of the SELDI technology, precisely because of their property of not vaporizing under the emission of laser light);
  2. Macromolecular compounds with altered, aggregate and retentive conformation (insoluble with high resistance to digestion eg PRIONS).

This is what, remember that this substance has been found within the most common and used hexavalently for children, in other words it is injected into newborns compulsorily.


Download: CORVELVA-Report-technical-MALDI-related-compound-insoluble-Infanrix-Hexa.pdf